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1

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Cromm, Philipp M., Crews, Craig M.

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.70 MB

english, 2017

2

Assessing Different E3 Ligases for Small Molecule-induced Protein Ubiquitination and Degradation

Ottis, Philipp, Toure, Momar, Cromm, Philipp M., Ko, Eunhwa, Gustafson, Jeffrey L., Crews, Craig M

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

3

Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure Degradation Relationships

Burslem, George M, Ottis, Philipp, Jaime-Figueroa, Saul, Morgan, Alicia, Cromm, Philipp, Toure, Momar, Crews, Craig

Journal:

Year:

2018

Language:

english

File:

PDF, 1.53 MB

english, 2018

4

Addressing Kinase-Independent Functions of Fak via PROTAC-mediated Degradation

Cromm, Philipp M., Samarasinghe, Kusal, Hines, John, Crews, Craig M

Journal:

Journal of the American Chemical Society

Year:

2018

Language:

english

File:

PDF, 964 KB

english, 2018

5

Small-molecule modulation of Ras signaling

Spiegel, Jochen, Cromm, Philipp M, Zimmermann, Gunther, Grossmann, Tom N, Waldmann, Herbert

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 1.59 MB

english, 2014

6

Direct Targeting of Rab-GTPase-Effector Interactions

Spiegel, Jochen, Cromm, Philipp M., Itzen, Aymelt, Goody, Roger S., Grossmann, Tom N., Waldmann, Herbert

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 1.54 MB

english, 2014

7

Hydrocarbon Stapled Peptides as Modulators of Biological Function

Cromm, Philipp M., Spiegel, Jochen, Grossmann, Tom N.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 5.43 MB

english, 2015

8

Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase

Cromm, Philipp M., Spiegel, Jochen, Kuechler, Philipp, Dietrich, Laura, Kriegesmann, Julia, Wendt, Mathias, Goody, Roger, Waldmann, Herbert, Grossmann, Tom N.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 20.73 MB

english, 2016

9

Direkte Modulation von Aktivität und Funktion kleiner GTPasen

Cromm, Philipp M., Spiegel, Jochen, Grossmann, Tom N., Waldmann, Herbert

Journal:

Angewandte Chemie

Year:

2015

Language:

german

File:

PDF, 8.45 MB

german, 2015

10

Direct Modulation of Small GTPase Activity and Function

Cromm, Philipp M., Spiegel, Jochen, Grossmann, Tom N., Waldmann, Herbert

Journal:

Angewandte Chemie International Edition

Year:

2015

Language:

english

File:

PDF, 8.92 MB

english, 2015

11

Direkte Modulation von Rab-GTPase-Effektor-Wechselwirkungen

Spiegel, Jochen, Cromm, Philipp M., Itzen, Aymelt, Goody, Roger S., Grossmann, Tom N., Waldmann, Herbert

Journal:

Angewandte Chemie

Year:

2014

Language:

german

File:

PDF, 1.54 MB

german, 2014

12

Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis

Cromm, Philipp M., Wallraven, Kerstin, Glas, Adrian, Bier, David, Fürstner, Alois, Ottmann, Christian, Grossmann, Tom N.

Journal:

Year:

2016

Language:

english

File:

PDF, 946 KB

english, 2016

13

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

Cromm, Philipp M., Schaubach, Sebastian, Spiegel, Jochen, Fürstner, Alois, Grossmann, Tom N., Waldmann, Herbert

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 831 KB

english, 2016

14

The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target

Cromm, Philipp M., Crews, Craig M.

Journal:

ACS Central Science

Year:

2017

Language:

english

File:

PDF, 2.40 MB

english, 2017

15

Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1

Durek, Thomas, Cromm, Philipp M., White, Andrew M., Schroeder, Christina I, Kaas, Quentin, Weidmann, Joachim, Ahmad Fuaad, Abdullah, Cheneval, Olivier, Harvey, Peta J., Daly, Norelle L., Zhou, Yang, D

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

16

Cover Feature: Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 (ChemBioChem 24/2019)

Cromm, Philipp M., Adihou, HÃ©lÃ¨ne, Kapoor, Shobhna, VazquezâChantada, Mercedes, Davey, Paul, Longmire, David, Hennes, Elisabeth, Hofer, Walter, KÃ¼chler, Philipp, Chiarparin, Elisabetta, Waldmann,

Journal:

Year:

2019

File:

PDF, 2.77 MB

2019

17

Prey for the Proteasome: Targeted Protein Degradation â A Medicinal ChemistÂ´s Perspective

Luh, Laura M., Scheib, Ulrike, JÃ¼nemann, Katrin, Wortmann, Lars, Brands, Michael, Cromm, Philipp M.

Journal:

Angewandte Chemie International Edition

Year:

2020

File:

PDF, 2.39 MB

2020

18

Prey for the Proteasome: Targeted Protein Degradation â A Medicinal ChemistÂ´s Perspective

Luh, Laura M., Scheib, Ulrike, JÃ¼nemann, Katrin, Wortmann, Lars, Brands, Michael, Cromm, Philipp M.

Journal:

Angewandte Chemie

Year:

2020

File:

PDF, 2.39 MB

2020

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